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HRID50258

反应详情

EQUATION

反应方程式

HRID 50258 的结构方程式

REACTANTS

反应物

2
结构：[Na+].[OH-]
HCID14798

Sodium Hydroxide

HNaO

结构：CCOC(=O)CCN(C(=O)c1ccc2c(c1)nc(COc1ccc(C(=N)N)cc1)n2C)c1ccccc1.Cl
HCID18412293

未命名化合物

PRODUCTS

生成物

1
结构：Cl.Cn1c(COc2ccc(C(=N)N)cc2)nc2cc(C(=O)N(CCC(=O)O)c3ccccc3)ccc21
HCID18412457

未命名化合物

收率 82%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCO.ClCCl
溶剂HCID21584144

Dichloromethane ethanol

C3H8Cl2O

PROCEDURE

实验过程

Prepared analogously to Example 26 from 1-methyl-2-[(4-amidinophenyl)oxymethyl]benzimidazol-5-yl-carboxylic acid-N-phenyl-N-(2-ethoxycarbonylethyl)amide hydrochloride and sodium hydroxide solution. Yield: 82% of theory, C26H25N5O4 (471.5); Rf value: 0.11 (silica gel; dichloromethane/ethanol=4:1); EKA mass spectrum: (M+H)+=472; (M+H+Na)++=247.6; (M+Na)+=494; (M+2Na)++=258.6.