HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(4-Cyanophenyl)glycine → Ethyl 3-(((2-(((4-cyanophenyl)amino)methyl)-1-methyl-1H-benzimidazol-5-yl)carbonyl)pyridin-2-ylamino)propionate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(4-Cyanophenyl)glycine | HCID 817965 | — |
| Reactant | N-(3-Amino-4-(methylamino)benzoyl)-N-2-pyridinyl-beta-alanine ethyl ester | HCID 11982993 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | Ethyl 3-(((2-(((4-cyanophenyl)amino)methyl)-1-methyl-1H-benzimidazol-5-yl)carbonyl)pyridin-2-ylamino)propionate | HCID 11627749 | 61% |
Reaction Steps
Prepared analogously to Example 25c from N-(4-cyanophenyl)glycine and 3-amino-4-methylaminobenzoic acid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide. Yield: 61% of theory; Rf value: 0.62 (silica gel; dichloromethane/methanol=19:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06710055B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-48eed80ffa4b4fb899e778a34e676b41 |
| Source note | uspto-grants-2004_03 |