HCID 131728284, compound → HCID 178455452, compound

Participants

Reaction Steps

To a solution of N,N′-bis(benzyloxycarbonyl)-N″-[2-(tert-butyl-dimethyl-silanyloxy)-1-(tert-butyl-dimethyl-silanyloxymethyl)-ethyl]-guanidine (12.48 g, 19.8 mmol) in 100 mL EtOH was added 5% Pd/C (0.5 g). The mixture was stirred under H2 at 50 psi. After 2 hours the mixture was filtered through a pad of celite and concentrated in vacuo to give N-[2-(tert-butyl-dimethyl-silanyloxy)-1-(tert-butyl-dimethyl-silanyloxymethyl)-ethyl]-guanidine (7.6 g, 106%) as a white foam: MS (M+H)=362.

Provenance & Evidence