反应详情

A mixture of toluene-4-sulfonic acid 2-isopropyl-quinolin-3-yl ester (1.31 g, 3.8 mmol), 0.64 g (11.4 mmol) of KOH in 10 mL of water, and 50 mL of p-dioxane was heated to refluxe for 1.5 hours until completion. The p-dioxane was removed under reduced pressure and the residue was diluted with water and acidified with 1N HCl to pH=6. The aqueous solution was extracted with ethyl acetate and the combined organic layers were washed with brine, dried (MgSO4) and concentrated under reduced pressure to afford quantitatively 0.71 g of 2-isopropyl-quinolin-3-ol

1. temperaturewas heated
2. customThe p-dioxane was removed under reduced pressure
3. additionthe residue was diluted with water
4. extractionThe aqueous solution was extracted with ethyl acetate
5. washthe combined organic layers were washed with brine
6. dry with materialdried (MgSO4)
7. concentrationconcentrated under reduced pressure