3-(4-Cyanophenyl)-propionic acid → 1-Methyl-2-[2-(4-cyanophenyl)-ethyl]-benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)-amide

Participants

Role	Name	HCID	Charge
Reactant	3-(4-Cyanophenyl)-propionic acid	HCID 9361742	—
Reactant	N-(3-Amino-4-(methylamino)benzoyl)-N-2-pyridinyl-beta-alanine ethyl ester	HCID 11982993	—
Solvent	Dichloromethane methanol	HCID 21226129	—
Product	1-Methyl-2-[2-(4-cyanophenyl)-ethyl]-benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)-amide	HCID 18412335	22%

Reaction Steps

Prepared analogously to Example 149a from 3-(4-cyanophenyl)propionic acid and 3-amino-4-methylaminobenzoic acid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide. Yield: 22% of theory; Rf value: 0.68 (silica gel; dichloromethane/methanol=19:1).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06710055B2
Source dataset	uspto-grants-2004_03
ORD ID	ord-833988e4c3014bf6b336a23f8e191a0e
Source note	uspto-grants-2004_03