HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-methyl-2-[2-(4-amidinophenyl)ethyl]benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Ammonium Carbonate | HCID 517111 | — |
| Reactant | 1-Methyl-2-[2-(4-cyanophenyl)-ethyl]-benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)-amide | HCID 18412335 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | 1-methyl-2-[2-(4-amidinophenyl)ethyl]benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide hydrochloride | HCID 18412669 | 85% |
Reaction Steps
Prepared analogously to Example 25d from 1-methyl-2-[2-(4-cyanophenyl)ethyl]benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide and ethanolic hydrochloric acid, ethanol, and ammonium carbonate. Yield: 85% of theory, C28H30N6O3 (498.6); Rf value: 0.30 (silica gel; dichloromethane/methanol=5:1); EKA mass spectrum: (M+H)+=499; (M+H+Na)++=261.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06710055B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-8c1392aef2634ab6a4fa016a84135892 |
| Source note | uspto-grants-2004_03 |