Phosphorus oxychloride → 4-Chloro-5-phenyl-6-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)furo[2,3-d]pyrimidine

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Reaction Steps

Compound 26 (60 mg, 0.149 mmol) was refluxed in phosphorous oxychloride (2 mL) for 1 h. The reaction mixture was concentrated and diluted with ice-cold water, brought to pH ˜8 with slow addition of saturated NaHCO3 and extracted with dichloromethane. The organic layer was dried over Na2SO4 and concentrated to afford 27, which was used in Step 3 without purification.

Provenance & Evidence