HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Diisopropylethylamine → 4-{4-[([1,3]Dithiolan-2-ylmethyl)-amino]-5-phenyl-furo[2,3-d]pyrimidin-6-yl}-phenol
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Diisopropylethylamine | HCID 81531 | — |
| Edukt | (1,3-Dithiolan-2-yl)methanamine | HCID 12372267 | — |
| Edukt | 4-(4-Chloro-5-phenyl-furo[2,3-d]pyrimidin-6-yl)-phenol | HCID 71470420 | — |
| Lösungsmittel | 1-Butanol | HCID 263 | — |
| Produkt | 4-{4-[([1,3]Dithiolan-2-ylmethyl)-amino]-5-phenyl-furo[2,3-d]pyrimidin-6-yl}-phenol | HCID 71470769 | — |
Reaktionsschritte
This compound was prepared by a method analogous to that for 70. Briefly, compound 79 was heated with C-[1,3]dithiolan-2-yl-methylamine and DIEA in 1-butanol to provide the title compound. MS: 422.1 (M+1). 1HNMR (DMSO-d6) ppm 9.86 (s, 1H), 8.33 (s, 1H), 7.59-7.51 (m, 5H), 7.26 (d, 2H, 7.00 Hz), 6.74 (d, 2H, 7.00 Hz), 5.35 (t, 1H), 4.69 (t, 1H, J=6.00 Hz), 3.64 (t, 2H, J=6.00 Hz), 3.13-3.05 (m, 4H).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07776867B2 |
| Quelldatensatz | uspto-grants-2010_08 |
| ORD ID | ord-d2cc3099a7ea4a319e58eeba90fb63f3 |
| Quellennotiz | uspto-grants-2010_08 |