Sodium Hydroxide → HCID 68462671, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 4-amino-5-phenyl-6-bromofuro-[2,3-d]pyrimidine (0.99 g, 3.4 mmol) in dimethyl formamide (10 mL) was added 2-(S)-(toluenesulfonyloxymethyl)-tetrahydrofuran (0.88 g, 3.4 mmol) and sodium hydroxide powder (0.15 g, 3.8 mmol). The resulting mixture was stirred at 120° C. for 2 h. The mixture was then partitioned between ethyl acetate and water and the organic layer washed with brine, dried over magnesium sulfate and concentrated under reduced pressure. The crude solid was purified by flash column chromatography (10% ethyl acetate/hexane) to yield the product as a white solid (0.48 g, 38%).

Provenance & Evidence