反应详情

温度

110 °C

A mixture of 14.0 g of 3-methylbenzyl chloride and 50.0 g of ethyl acrylate dissolved in 300 ml of dry toluene was heated to 110° C. Separatively, 3.0 g of 2,2'-azobisisobutyronitrile(AIBN) and 32.0 g of tri-n-butyltin hydride were dissolved in 200 ml of dry toluene, which was added to the above mixture over a period of 2 hours. This reaction mixture was further heated at the boiling temperature for 2 hours and then cooled to the ambient temperature. The residues obtained after removing the solvent from the mixture were purified by silica gel column chromatography to provide ethyl-4-(3-methylphenyl)butanoate.

1. additionwhich was added to the above mixture over a period of 2 hours
2. temperatureThis reaction mixture was further heated at the boiling temperature for 2 hours
3. temperaturecooled to the ambient temperature
4. customThe residues obtained
5. customafter removing the solvent from the mixture
6. customwere purified by silica gel column chromatography