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1-Methyl-4-(2-nitro-4-(trifluoromethyl)phenylsulfonyl)piperazine → 2-(4-Methylpiperazin-1-ylsulfonyl)-5-(trifluoromethyl)benzenamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Methyl-4-(2-nitro-4-(trifluoromethyl)phenylsulfonyl)piperazine | HCID 68463407 | — |
| 反応物 | HCID 178418361 | HCID 178418361 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 2-(4-Methylpiperazin-1-ylsulfonyl)-5-(trifluoromethyl)benzenamine | HCID 59427881 | — |
反応手順
1-methyl-4-(2-nitro-4-(trifluoromethyl)phenylsulfonyl)piperazine was dissolved in EtOH (20 mL) and the solution was purged with argon. Pd/C (365 mg, 0.34 mmol, 10%) was added to the solution, which was stirred for 3 days in an atmosphere of hydrogen gas. The mixture was again purged with argon, filtered through Celite and concentrated under reduced pressure to afford 2-(4-methylpiperazin-1-ylsulfonyl)-5-(trifluoromethyl)benzenamine. MS m/z=324 [M+H]+. Calc'd for C12H16F3N3O2S: 323.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07776869B2 |
| 出典データセット | uspto-grants-2010_08 |
| ORD ID | ord-fe3194fcb5fd4f988c4e7f92d31d19e7 |
| 出典メモ | uspto-grants-2010_08 |