HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-Methyl-2-[2-(4-amidinophenyl)ethyl]-benzimidazol-5-yl-carboxylic acid-n-phenyl-n-[2-(1h-tetrazol-5-yl)ethyl]-amide-hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ammonium Carbonate | HCID 517111 | — |
| Reactant | HCID 178480189 | HCID 178480189 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-Methyl-2-[2-(4-amidinophenyl)ethyl]-benzimidazol-5-yl-carboxylic acid-n-phenyl-n-[2-(1h-tetrazol-5-yl)ethyl]-amide-hydrochloride | HCID 178478915 | 92% |
Reaction Steps
Prepared analogously to Example 25d from 1-methyl-2-[2-(4-cyanophenyl)ethyl]benzimidazol-5-yl-carboxylic acid-N-phenyl-N-[2-(1H-tetrazol-5-yl)ethyl]amide and ethanolic hydrochloric acid, ethanol, and ammonium carbonate. Yield: 92% of theory, C27H27N9O (493.6); EKA mass spectrum: (M+H)+=494; (M+Na)+=516; (M+2H)++=258.7.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06710055B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-f9069f3321164360be902b6d2d717dc4 |
| Source note | uspto-grants-2004_03 |