HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(3-Amino-4-(methylamino)benzoyl)-N-2-pyridinyl-beta-alanine ethyl ester → 1-Methyl-2-[N-(4-cyanophenyl)-N-methyl-aminomethyl]-benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(3-Amino-4-(methylamino)benzoyl)-N-2-pyridinyl-beta-alanine ethyl ester | HCID 11982993 | — |
| Reactant | n-(4-Cyanophenyl)-n-methylglycine | HCID 18412499 | — |
| Reactant | Dichloromethane methanol | HCID 21226129 | — |
| Product | 1-Methyl-2-[N-(4-cyanophenyl)-N-methyl-aminomethyl]-benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)-amide | HCID 18412356 | 71% |
Reaction Steps
Prepared analogously to Example 25c from N-(4-cyanophenyl)-N-methylglycine and 3-amino-4-methylaminobenzoic acid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide. Yield: 71% of theory; Rf value: 0.66 (silica gel; dichloromethane/methanol=19:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06710055B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-080d1e32b7414be69126eae695f884b2 |
| Source note | uspto-grants-2004_03 |