3-(Trifluoromethoxy)aniline → 4-Chloro-3-iodo-N-(3-(trifluoromethoxy)phenyl)benzamide

HRID 502780Notes

Reaction equation

HRID 502780 reaction equation
[F:1][C:2]([F:12])([F:11])[O:3][C:4]1[CH:5]=[C:6]([CH:8]=[CH:9][CH:10]=1)[NH2:7].[Cl:13][C:14]1[CH:22]=[CH:21][C:17]([C:18](Cl)=[O:19])=[CH:16][C:15]=1[I:23]>>[Cl:13][C:14]1[CH:22]=[CH:21][C:17]([C:18]([NH:7][C:6]2[CH:8]=[CH:9][CH:10]=[C:4]([O:3][C:2]([F:11])([F:12])[F:1])[CH:5]=2)=[O:19])=[CH:16][C:15]=1[I:23]

Participants

3

Reactant 2

HCID 737533-(Trifluoromethoxy)anilineHCID 573499404-Chloro-3-iodobenzoyl chloride

Product 1

HCID 594280354-Chloro-3-iodo-N-(3-(trifluoromethoxy)phenyl)benzamide

Procedure

4-Chloro-3-iodo-N-(3-(trifluoromethoxy)phenyl)benzamide was synthesized from 3-(trifluoromethoxy)aniline and 4-chloro-3-iodobenzoylchloride according to the procedure described in Example 183, affording the title compound as a white solid. MS (M−H+) 439.8; Calculated for C14H8ClF3INO2: 441.

Sources & evidence

ORD record
ord-45220b2b7fe04d00b109e8c861aedfa9
Source dataset
uspto-grants-2010_08
Patent number
US07776869B2

Reaction notes

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