Sodium Hydroxide → HCID 18412734, compound

HRID 50284Notes

Reaction equation

Cl.Cl.[N:3]1[CH:8]=[CH:7][CH:6]=[C:5]([N:9]([CH2:33][CH2:34][C:35]([O:37]CC)=[O:36])[C:10]([C:12]2[CH:32]=[CH:31][C:15]3[N:16]([CH3:30])[C:17]([CH2:19][NH:20][C:21]4[CH:26]=[CH:25][C:24]([C:27](=[NH:29])[NH2:28])=[CH:23][CH:22]=4)=[N:18][C:14]=3[CH:13]=2)=[O:11])[CH:4]=1.[OH-].[Na+]>>[N:3]1[CH:8]=[CH:7][CH:6]=[C:5]([N:9]([CH2:33][CH2:34][C:35]([OH:37])=[O:36])[C:10]([C:12]2[CH:32]=[CH:31][C:15]3[N:16]([CH3:30])[C:17]([CH2:19][NH:20][C:21]4[CH:22]=[CH:23][C:24]([C:27](=[NH:28])[NH2:29])=[CH:25][CH:26]=4)=[N:18][C:14]=3[CH:13]=2)=[O:11])[CH:4]=1

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 18412700HCID 18412700, compound

Product 1

HCID 18412734HCID 18412734, compoundYield 85%

Procedure

Prepared analogously to Example 26 from 1-methyl-2-[N-(4-amidinophenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-(3-pyridyl)-N-(2-ethoxycarbonylethyl)amide dihydrochloride and sodium hydroxide solution. Yield: 85% of theory, C25H25N7O3 (471.5); EKA mass spectrum: (M+H)+=472; (M+2H)++=236.6; (M+2Na)++=258.6.

Sources & evidence

ORD record: ord-ce8d7c737d1b432ca5d3574a4deb28e5
Source dataset: uspto-grants-2004_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06710055B2

Reaction notes

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