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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 502856Generated: October 26, 2026

Trimethyl borate → 4-(Difluoromethoxy)benzeneboronic acid

https://huagongshe.com/reaction/502856

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrimethyl borateHCID 8470—
Reactant1-(Difluoromethoxy)-4-iodobenzeneHCID 2737008—
ReactantHCID 178418918HCID 178418918—
Product4-(Difluoromethoxy)benzeneboronic acidHCID 23082146—

Reaction Steps

In a departure from the procedure described above the compound is prepared from 4-difluoromethoxy-1-iodo-benzene using iPrMgCl to generate the arylmetal compound and trapping this intermediate with trimethyl borate.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07776830B2
Source datasetuspto-grants-2010_08
ORD IDord-342c09a282554710a5de8d59a6929584
Source noteuspto-grants-2010_08