HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-(Cyclopropylmethyl)-piperidine-4-carbonitrile hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Tert-butyl 4-cyano-4-(cyclopropylmethyl)piperidine-1-carboxylate | HCID 57425738 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 4-(Cyclopropylmethyl)-piperidine-4-carbonitrile hydrochloride | HCID 68619096 | — |
Reaction Steps
A sample of tert-butyl 4-cyano-4-(cyclopropylmethyl)piperidine-1-carboxylate (I-2, 3.6 g, 13.6 mmol) was treated with HCl (40 mL of a 4.0 M solution in dioxane) and stirred at room temperature for 2 h before being concentrated under reduced pressure to afford 4-(cyclopropylmethyl)-piperidine-4-carbonitrile hydrochloride (I-3, M+H+=165.1) which was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07776886B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-8a47bd4fc14546ac99740ff21c19e1db |
| Source note | uspto-grants-2010_08 |