4-(Cyclopropylmethyl)-1-(ethylsulfonyl)piperidine-4-carbonitrile → 1-[4-(Cyclopropylmethyl)-1-(ethylsulfonyl)piperidin-4-yl]methanamine

Participants

Reaction Steps

A solution of 4-(cyclopropylmethyl)-1-(ethylsulfonyl)piperidine-4-carbonitrile (I-4, 3.1 mg, 11.1 mmol) in 2 M NH3/MeOH (50 mL) was treated with excess Raney Ni and agitated under an atmosphere of H2 (40 psi) in a Parr apparatus. After 5 h, the reaction was filtered through Celite (MeOH wash) and concentrated under reduced pressure to afford 1-[4-(cyclopropylmethyl)-1-(ethylsulfonyl)-piperidin-4-yl]methanamine (I-5, M+H+=261.2) as a yellow oil. This material was used in subsequent reactions without further purification.

Provenance & Evidence