CJ-040714 → N-({1-[(4-Hydroxytetrahydro-2H-pyran-4-yl)methyl]piperidin-4-yl}methyl)-3-isopropyl-2-oxo-2,3-dihydro-1H-benzimidazole-1-carboxamide hydrochloride

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Reaction Steps

To a stirred solution of N-({1-[(4-hydroxytetrahydro-2H-pyran-4-yl)methyl]piperidin-4-yl}methyl)-3-isopropyl-2-oxo-2,3-dihydro-1H-benzimidazole-1-carboxamide (27.0 g, 62 mmol) in methanol (150 mL) was added 10% HCl-methanol (100 mL) at ambient temperature. After 30 min, the volatile materials were removed by evaporation. The resulting amorphous was precipitated by ethanol/diethylether. The precipitate was recrystallized from ethanol/diethylether (1:1) to give 26.5 g (90%) of title compound as a colorless powder.

Provenance & Evidence