反应详情

温度

190 °C

Potassium hydroxide (1.36 g) was added to an ethylene glycol (20 ml) solution of 1-(3-chloro-4-methyl-2-thienyl)cyclopentanecarbonitrile and the whole was stirred at 190° C. for 2 hours. After the reaction solution and ether were added to water, the aqueous layer was separated. An 1M aqueous hydrochloric acid solution was added to the aqueous layer to acidify the liquid and, after ether was added, the organic layer was separated. The layer was dried over anhydrous sodium sulfate and filtered and then the solvent was removed by evaporation under reduced pressure to obtain 1.59 g of 1-(3-chloro-4-methyl-2-thienyl)cyclopentanecarboxylic acid (pale brown solid).

1. customthe aqueous layer was separated
2. additionAn 1M aqueous hydrochloric acid solution was added to the aqueous layer
3. additionafter ether was added
4. customthe organic layer was separated
5. dry with materialThe layer was dried over anhydrous sodium sulfate
6. filtrationfiltered
7. customthe solvent was removed by evaporation under reduced pressure