HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 4-(Thiophen-2-yl)oxane-4-carbonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 4-(Thiophen-2-yl)oxane-4-carboxylic acid | HCID 19066254 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-(Thiophen-2-yl)oxane-4-carbonyl chloride | HCID 24229665 | — |
Reaction Steps
4-(2-Thienyl)tetrahydropyran-4-carboxylic acid was reacted with thionyl chloride and a catalytic amount of DMF in methylene chloride under heating to obtain 4-(2-thienyl)tetrahydropyran-4-carbonyl chloride. A THF solution of 4-(2-thienyl)tetrahydropyran-4-carbonyl chloride was added dropwise to a THF solution of hydrazine monohydrate and the whole was reacted at 0° C. to obtain 4-(2-thienyl)tetrahydropyran-4-carbohydrazide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07776897B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-23b80a9997984014b74ec45af4476216 |
| Source note | uspto-grants-2010_08 |