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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 502964Generated: November 1, 2026

Toluene → Methyl 3-[(cyclopropylamino)carbonyl]benzoate

https://huagongshe.com/reaction/502964

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTolueneHCID 1140—
ReactantDimethylformamideHCID 6228—
ReactantThionyl ChlorideHCID 24386—
Reactant3-(Methoxycarbonyl)benzoic acidHCID 601880—
SolventChloroformHCID 6212—
ProductMethyl 3-[(cyclopropylamino)carbonyl]benzoateHCID 47231565—

Reaction Steps

Toluene solution of 3-(Methoxycarbonyl)benzenecarboxylic acid, thionyl chloride and DMF (a catalytic amount) were heated under stirring. The reaction solution was dissolved in chloroform after evaporation under reduced pressure. After cyclopropylamine and triethylamine were added thereto and the whole was stirred at room temperature to obtain methyl 3-[(cyclopropylamino)carbonyl]benzoate.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07776897B2
Source datasetuspto-grants-2010_08
ORD IDord-7970b8c847374f64b42bda5eaa1518c8
Source noteuspto-grants-2010_08