Dichloromethane → HCID 9397001, compound

HRID 502967Notes

Reaction equation

HRID 502967 reaction equation
[NH:1]1[CH2:6][CH2:5][NH:4][CH2:3][C:2]1=[O:7].ClCCl.O1CCOCC1.[C:17]1([S:23](Cl)(=[O:25])=[O:24])[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>N1C=CC=CC=1>[C:17]1([S:23]([N:4]2[CH2:5][CH2:6][NH:1][C:2](=[O:7])[CH2:3]2)(=[O:25])=[O:24])[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Participants

6

Reactant 4

HCID 6344DichloromethaneHCID 7369Benzenesulfonyl chlorideHCID 312751,4-DioxaneHCID 231360Piperazin-2-one

Product 1

HCID 9397001HCID 9397001, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

2-piperazinone was suspended in a mixed solvent of dichloromethane and dioxane and then pyridine and benzenesulfonyl chloride were added thereto. After stirring at room temperature for 16 hours, the solvent was removed by evaporation and the resulting solid was suspended in 1N hydrochloric acid, filtered, and washed with diisopropyl ether to obtain 4-(phenylsulfonyl)-2-piperazinone.

Workup

  1. customthe solvent was removed by evaporation
  2. filtrationfiltered
  3. washwashed with diisopropyl ether

Sources & evidence

ORD record
ord-2cae02dca9454d9d85e66c87278e51b3
Source dataset
uspto-grants-2010_08
Patent number
US07776897B2

Reaction notes

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