Hydrogen chloride-ethyl acetate → HCID 68467402, compound

HRID 502974Notes

Reaction equation

HRID 502974 reaction equation
[CH3:1][C:2]([NH:17]C(=O)OC(C)(C)C)([C:4]1[N:8]([CH3:9])[C:7]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[CH3:16])=[N:6][N:5]=1)[CH3:3].[ClH:25].C(OCC)(=O)C>C(O)C>[ClH:25].[ClH:25].[CH3:9][N:8]1[C:7]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[CH3:16])=[N:6][N:5]=[C:4]1[C:2]([NH2:17])([CH3:1])[CH3:3]

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 86616224HCID 86616224, compound

Product 1

HCID 68467402HCID 68467402, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

tert-Butyl {1-methyl-1-[4-methyl-5-(2-methylphenyl)-1,2,4-triazol-3-yl]ethyl}carbamate was reacted with a 4M hydrochloric acid-ethyl acetate solution in ethanol under heating to obtain 2-[4-methyl-5-(2-methylphenyl)-1,2,4-triazol-3-yl]propan-2-amine dihydrochloride.

Workup

  1. temperatureunder heating

Sources & evidence

ORD record
ord-d609f3afacf14d398ae67b5adf5784e9
Source dataset
uspto-grants-2010_08
Patent number
US07776897B2

Reaction notes

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