Methyl isothiocyanate → HCID 86616225, compound

HRID 502978Notes

Reaction equation

HRID 502978 reaction equation
[CH3:1][N:2]=[C:3]=[S:4].[Cl:5][C:6]1[C:10]([CH3:11])=[CH:9][S:8][C:7]=1[C:12]1([C:17]([NH:19][NH2:20])=[O:18])[CH2:16][CH2:15][CH2:14][CH2:13]1>C(O)C>[Cl:5][C:6]1[C:10]([CH3:11])=[CH:9][S:8][C:7]=1[C:12]1([C:17]([NH:19][NH:20][C:3](=[S:4])[NH:2][CH3:1])=[O:18])[CH2:16][CH2:15][CH2:14][CH2:13]1

Participants

4

Reactant 2

HCID 11167Methyl isothiocyanateHCID 68467032HCID 68467032, compound

Product 1

HCID 86616225HCID 86616225, compoundYield 65.1%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
75 °C

Procedure

Methyl isothiocyanate (62 mg) was added to an ethanol (10 ml) solution of 1-(3-chloro-4-methyl-2-thienyl)cyclopentanecarbohydrazide (200 mg), followed by stirring at 75° C. for 3 hours. The reaction solution was subjected to evaporation under reduced pressure and the resulting crude product washed with ether to obtain 167 mg of 2-{[1-(3-chloro-4-methyl-2-thienyl)cyclopentyl]carbonyl}-N-methylhydrazinecarbothioamide.

Workup

  1. customThe reaction solution was subjected to evaporation under reduced pressure
  2. washthe resulting crude product washed with ether

Sources & evidence

ORD record
ord-d0e6df7466cb401e83f59b89c2a39837
Source dataset
uspto-grants-2010_08
Patent number
US07776897B2

Reaction notes

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