HuagongsheHuagongshe Chemistry Print Report · For research reference only
Carbonochloridic acid, cyclohexyl ester → methyl 3-(N-[2-[[4-(N-cyclohexyloxycarbonylcarbamimidoyl)anilino]methyl]-1-methylbenzimidazole-5-carbonyl]anilino)propanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Carbonochloridic acid, cyclohexyl ester | HCID 83262 | — |
| Reactant | 1-Methyl-2-[N-(4-amidinophenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-phenyl-N-(2-methoxycarbonylethyl)amide Hydrochloride | HCID 18412701 | — |
| Solvent | Dichloromethane ethanol | HCID 21584144 | — |
| Product | methyl 3-(N-[2-[[4-(N-cyclohexyloxycarbonylcarbamimidoyl)anilino]methyl]-1-methylbenzimidazole-5-carbonyl]anilino)propanoate | HCID 140435600 | 25% |
Reaction Steps
Prepared analogously to Example 90 from 1-methyl-2-[N-(4-amidinophenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-phenyl-N-(2-methoxycarbonylethyl)amide hydrochloride and cyclohexyl chloroformate. Yield: 25% of theory, C34H38N6O5 (610.7); Rf value: 0.44 (silica gel; dichloromethane/ethanol=19:1); EKA mass spectrum: (M+H)+=611; (M+2H)++=306.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06710055B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-956d97a91c3947c9a2927c0e769c4305 |
| Source note | uspto-grants-2004_03 |