Hydrochloric Acid → HCID 68466223, compound

Participants

Reaction Steps

1M Hydrochloric acid was added to a THF (10 ml) solution of 3-[7,7-dimethyl-2-(2-thienyl)-6,8-dioxaspiro[3,5]non-2-yl]-5,6,7,8,9,10-hexahydro[1,2,4]triazolo[4,3-a]azocine (2270 mg) and the whole was stirred at room temperature for 30 minutes. The reaction solution and chloroform were added to a saturated aqueous sodium hydrogen carbonate solution and then the organic layer was separated. Furthermore, the organic layer washed with a saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, and filtered and then the solvent was removed by evaporation under reduced pressure. The resulting crude product was purified by flash column chromatography (chloroform:methanol=9:1) to obtain 1862 mg of [3-(5,6,7,8,9,10-hexahydro[1,2,4]triazolo[4,3-a]azocin-3-yl)-3-(2-thienyl)cyclobutane-1,1-diyl]dimethanol (colorless solid).

Provenance & Evidence