HuagongsheHuagongshe Chemistry Print Report · For research reference only
Carbonochloridic acid, 2-(methylsulfonyl)ethyl ester → ethyl 3-(N-[1-methyl-2-[[4-[N-(2-methylsulfonylethoxycarbonyl)carbamimidoyl]anilino]methyl]benzimidazole-5-carbonyl]anilino)propanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Carbonochloridic acid, 2-(methylsulfonyl)ethyl ester | HCID 104458 | — |
| Reactant | 1-Methyl-2-[N-(4-amidinophenyl)-aminomethyl]-benzimidazol-5-yl-carboxylicacid-N-phenyl-N-(2-ethoxycarbonylethyl)-amide-hydrochloride | HCID 18412553 | — |
| Solvent | Dichloromethane ethanol | HCID 21584144 | — |
| Product | ethyl 3-(N-[1-methyl-2-[[4-[N-(2-methylsulfonylethoxycarbonyl)carbamimidoyl]anilino]methyl]benzimidazole-5-carbonyl]anilino)propanoate | HCID 140435587 | 66% |
Reaction Steps
Prepared analogously to Example 90 from 1-methyl-2-[N-(4-amidinophenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-phenyl-N-(2-ethoxycarbonylethyl)amide hydrochloride and 2-(methylsulfonyl)ethyl chloroformate. Yield: 66% of theory, C32H36N6O7S (648.8); Rf value: 0.44 (silica gel; dichloromethane/ethanol=19:1); EKA mass spectrum: (M+H)+=649; (M+H+Na)++=336(M+2H)++=325.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06710055B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-02468be8aaef47d6928b4d949e40a941 |
| Source note | uspto-grants-2004_03 |