8-Methoxy-2,3,4,5,6,7-hexahydroazocine → 3-[1-(1-Benzyl-4-piperidinyl)cyclopentyl]-5,6,7,8,9,10-hexahydro[1,2,4]triazolo[4,3-a]azocine

참여 물질

반응 단계

1-(1-Benzylpiperidin-4-yl)cyclopentane-1-carbohydrazide (1.04 g) and 8-methoxy-2,3,4,5,6,7-hexahydroazocine (1.46 g) were reacted in toluene (10 ml) under heating to obtain 3-[1-(1-benzyl-4-piperidinyl)cyclopentyl]-5,6,7,8,9,10-hexahydro[1,2,4]triazolo[4,3-a]azocine (0.686 g). The resulting compound was reacted in ethanol under a hydrogen atmosphere using 10% palladium-active carbon (0.14 g) as a catalyst and, after filtration through celite, the resulting solution was concentrated to obtain 3-(1-piperidin-4-ylcyclopentyl)-5,6,7,8,9,10-hexahydro[1,2,4]triazolo[4,3-a]azocine (0.610 g).

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