1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride → HCID 68465430, compound

Participants

Reaction Steps

HOBt hydrate (82 mg), WSC hydrochloride (103 mg), and ammonia water (33 μl) were added to a THF (1 ml) and DMF (1 ml) solution of 4-[5-(1-anilino-1-methylethyl)-4-methyl-4H-1,2,4-triazol-3-yl]benzoic acid (150 mg) at room temperature, followed by stirring at the same temperature overnight. After most of the solvent was removed by evaporation under reduced pressure, water was added thereto and the whole was extracted four times with ethyl acetate. The organic layer washed with brine, dried over anhydrous magnesium sulfate, and filtered, and then the solvent was removed by evaporation. Ethyl acetate was added to the resulting white crystals, which was filtered and washed with ethyl acetate to obtain 120 mg of 4-[5-(1-anilino-1-methylethyl)-4-methyl-4H-1,2,4-triazol-3-yl]benzamide (white crystals).

Provenance & Evidence