HuagongsheHuagongshe Chemistry Print Report · For research reference only
Carbonochloridic acid, heptyl ester → methyl 3-(N-[2-[[4-(N-heptoxycarbonylcarbamimidoyl)anilino]methyl]-1-methylbenzimidazole-5-carbonyl]anilino)propanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Carbonochloridic acid, heptyl ester | HCID 118547 | — |
| Reactant | 1-Methyl-2-[N-(4-amidinophenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-phenyl-N-(2-methoxycarbonylethyl)amide Hydrochloride | HCID 18412701 | — |
| Solvent | Dichloromethane ethanol | HCID 21584144 | — |
| Product | methyl 3-(N-[2-[[4-(N-heptoxycarbonylcarbamimidoyl)anilino]methyl]-1-methylbenzimidazole-5-carbonyl]anilino)propanoate | HCID 140435595 | 43% |
Reaction Steps
Prepared analogously to Example 90 from 1-methyl-2-[N-(4-amidinophenyl)amino methyl]benzimidazol-5-yl-carboxylic acid-N-phenyl-N-(2-methoxycarbonylethyl)amide hydrochloride and n-heptyl chloroformate. Yield: 43% of theory, C35H42N6O5 (626.8); Rf value: 0.40 (silica gel; dichloromethane/ethanol=19:1); EKA mass spectrum: (M+H)+=627; (M+H+Na)++=325; (M+Na)+=649.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06710055B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-754aa81970034f9c998c7def7b2b9398 |
| Source note | uspto-grants-2004_03 |