Hydrochloric Acid → HCID 68516982, compound

Participants

Reaction Conditions

Reaction Steps

At a solution of N-[4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenylsulfonyl]benzensulfonamide (1 g, 2.262 mmol) in pyridine (50 ml) cooled at 0° C., 4-chlorobutyrylchloride was added dropwise (0.294 ml), the solution was maintained under stirring for 10 minutes at 0° C., the temperature was then raised to room temperature and the solution was maintained under stirring for 2 hours. Then HCl was added (50 ml, 0.1 N) and the mixture was extracted with CH2Cl2. The combined organic phases were washed with water, dried and the solvent was evaporated at reduced pressure. The crude compound as purified by chromatography on a silica gel column with n-hehan/ethyl acetate 8/2 as eluent to give 0.400 mg of product 4A.

Provenance & Evidence