Ammonia → 4-(1-Methylethyl)benzenesulfonamide

HRID 503030Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 503030
[NH3:1].[CH3:2][CH:3]([C:5]1[CH:10]=[CH:9][C:8]([S:11](Cl)(=[O:13])=[O:12])=[CH:7][CH:6]=1)[CH3:4]>O1CCCC1>[CH3:2][CH:3]([C:5]1[CH:10]=[CH:9][C:8]([S:11]([NH2:1])(=[O:13])=[O:12])=[CH:7][CH:6]=1)[CH3:4]

Komponenten

4

Edukt 2

HCID 222Ammonia2×HCID 27348824-(Propan-2-yl)benzene-1-sulfonyl chloride

Produkt 1

HCID 2323144-(1-Methylethyl)benzenesulfonamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To concentrated aqueous ammonia (1.75 mL) in tetrahydrofuran (50 mL) at 0° C. with stirring was added over 2 min via syringe 4-(1-methylethyl)benzenesulfonyl chloride (3.3 g). A white precipitate was observed. Additional concentrated aqueous ammonia (1.75 mL) was added after 5 min. After 4 h volatiles were evaporated and the residue partitioned between EtOAc and aqueous NaHCO3. The organic layer was washed with brine, dried (Na2SO4) and volatiles evaporated to give the title crude compound as a colourless powder that was used without further purification.

Aufarbeitung

  1. customAfter 4 h volatiles were evaporated
  2. customthe residue partitioned between EtOAc and aqueous NaHCO3
  3. washThe organic layer was washed with brine
  4. dry with materialdried (Na2SO4)
  5. customvolatiles evaporated

Quellen und Nachweise

ORD-Eintrag
ord-c53d51f13a85481e9858f0e67ed4a949
Quelldatensatz
uspto-grants-2010_08
Patentnummer
US07776904B2

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