反应详情

To concentrated aqueous ammonia (1.75 mL) in tetrahydrofuran (50 mL) at 0° C. with stirring was added over 2 min via syringe 4-(1-methylethyl)benzenesulfonyl chloride (3.3 g). A white precipitate was observed. Additional concentrated aqueous ammonia (1.75 mL) was added after 5 min. After 4 h volatiles were evaporated and the residue partitioned between EtOAc and aqueous NaHCO3. The organic layer was washed with brine, dried (Na2SO4) and volatiles evaporated to give the title crude compound as a colourless powder that was used without further purification.

1. customAfter 4 h volatiles were evaporated
2. customthe residue partitioned between EtOAc and aqueous NaHCO3
3. washThe organic layer was washed with brine
4. dry with materialdried (Na2SO4)
5. customvolatiles evaporated