HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hexyl chloroformate → methyl 3-(N-[2-[[4-(N-hexoxycarbonylcarbamimidoyl)anilino]methyl]-1-methylbenzimidazole-5-carbonyl]anilino)propanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hexyl chloroformate | HCID 22466 | — |
| Reactant | Dichloromethane ethanol | HCID 21584144 | — |
| Reactant | 1-methyl-2-[N-(4-amidinophenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-phenyl-N-(2-methoxy-carbonylethyl)amide hydrochloride | HCID 86587044 | — |
| Product | methyl 3-(N-[2-[[4-(N-hexoxycarbonylcarbamimidoyl)anilino]methyl]-1-methylbenzimidazole-5-carbonyl]anilino)propanoate | HCID 140409622 | 54% |
Reaction Steps
Prepared analogously to Example 90 from 1-methyl-2-[N-(4-amidinophenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-phenyl-N-(2-methoxy-carbonylethyl)amide hydrochloride and n-hexyl chloroformate. Yield: 54% of theory, C34H40N6O5 (612.7); Rf value: 0.45 (silica gel; dichloromethane/ethanol=19:1); EKA mass spectrum: (M+H)+=613.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06710055B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-c14b881417f9430c8bc76c3ab3fc2b52 |
| Source note | uspto-grants-2004_03 |