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Hexyl chloroformate → propyl 3-(N-[2-[[4-(N-hexoxycarbonylcarbamimidoyl)anilino]methyl]-1-methylbenzimidazole-5-carbonyl]anilino)propanoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hexyl chloroformate | HCID 22466 | — |
| 反応物 | 1-methyl-2-[N-(4-amidinophenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-phenyl-N-(2-n-propyloxycarbonylethyl)amide hydrochloride | HCID 18412549 | — |
| 溶媒 | Dichloromethane ethanol | HCID 21584144 | — |
| 生成物 | propyl 3-(N-[2-[[4-(N-hexoxycarbonylcarbamimidoyl)anilino]methyl]-1-methylbenzimidazole-5-carbonyl]anilino)propanoate | HCID 140409621 | 31% |
反応手順
Prepared analogously to Example 90 from 1-methyl-2-[N-(4-amidinophenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-phenyl-N-(2-n-propyloxycarbonylethyl)amide hydrochloride and n-hexyl chloroformate. Yield: 31% of theory, C36H44N6O5 (640.8); Rf value: 0.42 (silica gel; dichloromethane/ethanol=19:1); EKA mass spectrum: (M+H)+=641; (M+H+Na)++=332; (M+Na)+=663.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06710055B2 |
| 出典データセット | uspto-grants-2004_03 |
| ORD ID | ord-5f56ebaa3ef54374a7e5dcf450a22f3b |
| 出典メモ | uspto-grants-2004_03 |