反应详情

To a solution of 16.0 g of 1-(2,2-diethoxyethoxy)-4-fluorobenzene in 50 ml n-hexane was added 3.2 g of amberlyst 15 at room temperature. After the mixture was treated in a sealed tube at 200° C. for 11 hours, the amberlyst 15 was filtered off. The solvent was evaporated, and the crude product was purified and separated by silica gel column chromatography (n-hexane), to give 4.8 g of the title compound as a colorless oil.

1. additionAfter the mixture was treated in a sealed tube at 200° C. for 11 hours
2. filtrationthe amberlyst 15 was filtered off
3. customThe solvent was evaporated
4. customthe crude product was purified
5. customseparated by silica gel column chromatography (n-hexane)