HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzoyl chloride → methyl 3-[[2-[[4-(N-benzoylcarbamimidoyl)anilino]methyl]-1-methylbenzimidazole-5-carbonyl]-pyridin-2-ylamino]propanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzoyl chloride | HCID 7412 | — |
| Reactant | 1-Methyl-2-[N-(4-amidinophenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-methoxycarbonylethyl)amide Hydrochloride | HCID 18412516 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | methyl 3-[[2-[[4-(N-benzoylcarbamimidoyl)anilino]methyl]-1-methylbenzimidazole-5-carbonyl]-pyridin-2-ylamino]propanoate | HCID 140435588 | 62% |
Reaction Steps
Prepared analogously to Example 90 from 1-methyl-2-[N-(4-amidinophenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-methoxycarbonylethyl)amide hydrochloride and benzoyl chloride. Yield: 62% of theory, C33H31N7O4 (589.7); Rf value: 0.50 (silica gel; dichloromethane/methanol=9:1); EKA mass spectrum: (M+H)+=590; (M+Na)+=612.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06710055B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-c5ed15d587ac479ca8b857462ea45a62 |
| Source note | uspto-grants-2004_03 |