Ammonium Chloride → (5-Bromo-2,4-difluoro-phenyl)-(3-fluoro-phenyl)-methanol

HRID 503162Notes

Reaction equation

Br[C:2]1[CH:7]=[C:6]([Br:8])[C:5]([F:9])=[CH:4][C:3]=1[F:10].C([Li])CCC.[F:16][C:17]1[CH:18]=[C:19]([CH:22]=[CH:23][CH:24]=1)[CH:20]=[O:21].[Cl-].[NH4+]>C(OCC)C.CCCCCC>[Br:8][C:6]1[C:5]([F:9])=[CH:4][C:3]([F:10])=[C:2]([CH:20]([C:19]2[CH:22]=[CH:23][CH:24]=[C:17]([F:16])[CH:18]=2)[OH:21])[CH:7]=1

Participants

Conditions

Temperature: -70 °C

Procedure

A total of 2.02 g of 1,5-dibromo-2,4-difluorobenzene obtained in Production Example II-5-a was dissolved in 38 ml of diethyl ether, and 4.9 ml of a 1.58 M solution of n-butyllithium in hexane was added under stirring at −70° C. After stirring for 1 hour, 4.9 ml of m-fluorobenzaldehyde was added and the mixture was stirred for 15 minutes. Saturated aqueous ammonium chloride solution was added to the reaction mixture, followed by extracting with ethyl acetate. The resulting organic layer was washed with brine, dried over magnesium sulfate and the solvent was evaporated. The residue was purified and separated by silica gel column chromatography (ethyl acetate:hexane=1:10), to give 0.96 g of the title compound.

Workup

stirringAfter stirring for 1 hour
stirringthe mixture was stirred for 15 minutes
extractionby extracting with ethyl acetate
washThe resulting organic layer was washed with brine
dry with materialdried over magnesium sulfate
customthe solvent was evaporated
customThe residue was purified
customseparated by silica gel column chromatography (ethyl acetate:hexane=1:10)

Sources & evidence

ORD record: ord-94206b409d9c4e3b89aa1e6ca590e3d1
Source dataset: uspto-grants-2010_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07776890B2

Reaction notes

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