反应详情

A total of 3.84 g of 2-amino-4-fluoro-benzoic acid ethyl ester obtained in Production Example II-7-a was dissolved in 50 ml of pyridine, 1.64 ml of acetyl chloride was added under ice-cooling, and the mixture was stirred for 1 hours. The reaction mixture was diluted with water and was extracted with diethyl ether. The resulting organic layer was washed with 1 N hydrochloric acid and brine, dried over magnesium sulfate, and then evaporated, to give 4.0 g of the title compound.

1. temperaturecooling
2. extractionwas extracted with diethyl ether
3. washThe resulting organic layer was washed with 1 N hydrochloric acid and brine
4. dry with materialdried over magnesium sulfate
5. customevaporated