HuagongsheHuagongshe Chemistry Print Report · For research reference only
Nicotinoyl chloride → methyl 3-[[1-methyl-2-[[4-[N-(pyridine-3-carbonyl)carbamimidoyl]anilino]methyl]benzimidazole-5-carbonyl]-pyridin-2-ylamino]propanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Nicotinoyl chloride | HCID 82604 | — |
| Reactant | 1-Methyl-2-[N-(4-amidinophenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-methoxycarbonylethyl)amide Hydrochloride | HCID 18412516 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | methyl 3-[[1-methyl-2-[[4-[N-(pyridine-3-carbonyl)carbamimidoyl]anilino]methyl]benzimidazole-5-carbonyl]-pyridin-2-ylamino]propanoate | HCID 140409616 | 40% |
Reaction Steps
Prepared analogously to Example 90 from 1-methyl-2-[N-(4-amidinophenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-methoxycarbonylethyl)amide hydrochloride and nicotinic acid chloride. Yield: 40% of theory, C32H30N8O4 (590.7); Rf value: 0.47 (silica gel; dichloromethane/methanol=9:1); EKA mass spectrum: (M+H)+=591; (M+H+Na)++=307; (M+Na)+=613.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06710055B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-c0d3f073985f4b9faebac40e87933729 |
| Source note | uspto-grants-2004_03 |