Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hexyl chloroformate → Dabigatran Etexilate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hexyl chloroformate | HCID 22466 | — |
| 반응물 | Ethyl 3-(2-(((4-carbamimidoylphenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo(d)imidazole-5-carboxamido)propanoate hydrochloride | HCID 18412337 | — |
| 용매 | Dichloromethane methanol | HCID 21226129 | — |
| 생성물 | Dabigatran Etexilate | HCID 135565674 | 51% |
반응 단계
Prepared analogously to Example 90 from 1-methyl-2-[N-(4-amidinophenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide hydrochloride and n-hexyl chloroformate. Yield: 51% of theory, C34H41N7O5 (627.8); Rf value: 0.53 (silica gel; dichloromethane/methanol=9:1); EKA mass spectrum: (M+H)+=628; (M+H+Na)++=325.7; (M+2H)++=314.7.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06710055B2 |
| 출처 데이터셋 | uspto-grants-2004_03 |
| ORD ID | ord-6c606f1e0acb49d082644cf456564974 |
| 출처 메모 | uspto-grants-2004_03 |