HuagongsheHuagongshe Chemistry Print Report · For research reference only
Carbonochloridic acid, octyl ester → O-Octyl Dabigatran Ethyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Carbonochloridic acid, octyl ester | HCID 81956 | — |
| Reactant | Ethyl 3-(2-(((4-carbamimidoylphenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo(d)imidazole-5-carboxamido)propanoate hydrochloride | HCID 18412337 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | O-Octyl Dabigatran Ethyl Ester | HCID 140409595 | 57% |
Reaction Steps
Prepared analogously to Example 90 from 1-methyl-2-[N-(4-amidinophenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide hydrochloride and n-octyl chloroformate. Yield: 57% of theory, C36H45N7O5 (655.8); Rf value: 0.46 (silica gel; dichloromethane/methanol=9:1); EKA mass spectrum: (M+H)+=656; (M+H+Na)++=339.7; (M+2H)++=328.7.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06710055B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-c6452b3db441400c98ce733667c5168c |
| Source note | uspto-grants-2004_03 |