HuagongsheHuagongshe Chemistry Print Report · For research reference only
Carbonochloridic acid, 2-(methylsulfonyl)ethyl ester → ethyl 2-[[1-methyl-2-[[4-[N-(2-methylsulfonylethoxycarbonyl)carbamimidoyl]anilino]methyl]benzimidazole-5-carbonyl]-pyridin-2-ylamino]acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Carbonochloridic acid, 2-(methylsulfonyl)ethyl ester | HCID 104458 | — |
| Reactant | HCID 18412300 | HCID 18412300 | — |
| Solvent | Dichloromethane ethanol | HCID 21584144 | — |
| Product | ethyl 2-[[1-methyl-2-[[4-[N-(2-methylsulfonylethoxycarbonyl)carbamimidoyl]anilino]methyl]benzimidazole-5-carbonyl]-pyridin-2-ylamino]acetate | HCID 140409597 | 72% |
Reaction Steps
Prepared analogously to Example 90 from 1-methyl-2-[N-(4-amidinophenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-ethoxycarbonylmethylamide hydrochloride and 2-(methylsulfonyl)ethyl chloroformate. Yield: 72% of theory, C30H33N7O7S (635.7); Rf value: 0.23 (silica gel; dichloromethane/ethanol=19:1); EKA mass spectrum: (M+H)+=636; (M+H+Na)++=329.8.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06710055B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-274c7b37a4f04b3b97210d67b1b31259 |
| Source note | uspto-grants-2004_03 |