p-Toluenesulfonic acid → HCID 57556922, compound

Participants

Reaction Steps

A solution of compound 6 (8.5 g), triethylorthoformate (7.55 mL), p-toluene sulphonic acid (2 g) in THF (75 mL) was stirred at reflux for 4 hours. The reaction mixture was concentrated under reduced pressure. The residue was dissolved in CH2Cl2 (600 mL), washed with 20% NaHCO3 solution and brine, successively, and dried over anhydrous Na2SO4. The solvent was removed under reduced pressure and the crude product was purified by column chromatography on silica gel using a 4:6 mixture of ethyl acetate and pet-ether as the eluent to afford compound 7 (7.9 g, 77%) as a solid.

Provenance & Evidence