HCID 67484508, compound → HCID 86626711, compound

Participants

Reaction Steps

To a solution of 19a (0.6 g, 1.5 mmol) in ethanol (20 ml) was added platinium oxide (0.15 g) and the resultant mixture was hydrogenated at ambient pressure until the hydrogen uptake had ceased. Filtration through celite and concentration of the filtrate in vacuo left 20a, which was taken directly into the next step. The following compounds were prepared in analogy herewith: N1-[3-(2-Ethyl-2H-[1,2,4]triazol-3-ylmethoxymethyl)-phenyl]-4-trifluoromethyl-benzene-1,2-diamine (20b) from 19b 4-Methyl-N1-[3-(2-methyl-2H-[1,2,4]triazol-3-ylmethoxymethyl)-phenyl]-benzene-1,2-diamine (20c) from 19c 1-{3-Amino-4-[3-(2-methyl-2H-[1,2,4]triazol-3-ylmethoxymethyl)-phenylamino]-phenyl}-ethanone (20d) from 19d

Provenance & Evidence