Potassium Carbonate → HCID 12001774, compound

Participants

Reaction Steps

Compound 27 was prepared from compound 7 by the method described in Example 2. To a solution of compound 27 (3 g, 1.01 mmol) in DMF (30 ml) was added potassium carbonate (2 g; 1.45 mmol) and 3,4-difluorobenzylamine (1.43 ml; 1.2 mmol) and the resultant mixture was stirred at ambient conditions over night. Aqueous work-up followed by column chromatography afforded compound 28a (0.9 g). LC-ESI-HRMS of [M+H]+ shows 422.1697 Da. Calc. 422.167925 Da, dev. 4.2 ppm

Provenance & Evidence