Butyl chloroformate → ethyl 3-[[2-[[4-(N-butoxycarbonylcarbamimidoyl)-N-methylanilino]methyl]-1-methylbenzimidazole-5-carbonyl]-pyridin-2-ylamino]propanoate

Participants

Role	Name	HCID	Charge
Reactant	Butyl chloroformate	HCID 61140	—
Reactant	1-methyl-2-[N-(4-amidinophenyl)-N-methylaminomethyl]benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide hydrochloride	HCID 18412298	—
Product	ethyl 3-[[2-[[4-(N-butoxycarbonylcarbamimidoyl)-N-methylanilino]methyl]-1-methylbenzimidazole-5-carbonyl]-pyridin-2-ylamino]propanoate	HCID 140409625	34%

Reaction Steps

Prepared analogously to Example 90 from 1-methyl-2-[N-(4-amidinophenyl)-N-methylaminomethyl]benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide hydrochloride and n-butyl chloroformate. Yield: 34% of theory, C33H39N7O5 (613.7); EKA mass spectrum: (M+H)+=614; (M+H+Na)++=318.7; (M+Na)+=636.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06710055B2
Source dataset	uspto-grants-2004_03
ORD ID	ord-a109a0f0c7ce4957a86a7eb58ca4607b
Source note	uspto-grants-2004_03