Benzoyl chloride → ethyl 3-[[2-[[4-(N-benzoylcarbamimidoyl)-N-methylanilino]methyl]-1-methylbenzimidazole-5-carbonyl]-pyridin-2-ylamino]propanoate

Participants

Role	Name	HCID	Charge
Reactant	Benzoyl chloride	HCID 7412	—
Reactant	1-methyl-2-[N-(4-amidinophenyl)-N-methylaminomethyl]benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide hydrochloride	HCID 18412298	—
Product	ethyl 3-[[2-[[4-(N-benzoylcarbamimidoyl)-N-methylanilino]methyl]-1-methylbenzimidazole-5-carbonyl]-pyridin-2-ylamino]propanoate	HCID 140435599	63%

Reaction Steps

Prepared analogously to Example 90 from 1-methyl-2-[N-(4-amidinophenyl)-N-methylaminomethyl]benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide hydrochloride and benzoyl chloride. Yield: 63% of theory, C35H35N7O4 (617.7); EKA mass spectrum: (M+H)+=618; (M+H+Na)++=320.7; (M+Na)+=640.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06710055B2
Source dataset	uspto-grants-2004_03
ORD ID	ord-9bc7e40d42294651b5316c104711be38
Source note	uspto-grants-2004_03