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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 50329Generated: October 29, 2026

Hydrochloric Acid → 1-Methyl-2-[-(4-amidinophenvl)aminomethyl]benzimidazol-5-yl-tert-butyl Ketone Hydrochloride

https://huagongshe.com/reaction/50329

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
ReactantAmmonium CarbonateHCID 517111—
Reactant1-methyl-2-[N-(4-cyanophenyl)aminomethyl]benzimidazol-5-yl-tert-butyl ketoneHCID 18474037—
SolventEthanolHCID 702—
Product1-Methyl-2-[-(4-amidinophenvl)aminomethyl]benzimidazol-5-yl-tert-butyl Ketone HydrochlorideHCID 1847404659%

Reaction Steps

Prepared analogously to Example 25d from 1-methyl-2-[N-(4-cyanophenyl)aminomethyl]benzimidazol-5-yl-tert-butyl ketone, ethanolic hydrochloric acid, ethanol, and ammonium carbonate. Yield: 59% of theory, C21H25N5O (363.5); EKA mass spectrum: (M+H)+=364.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06710055B2
Source datasetuspto-grants-2004_03
ORD IDord-6a55e17e734142fc9e3615e73f3ae154
Source noteuspto-grants-2004_03