HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,12-Bis(2-amino-3,4,5,6-tetrahydropyrimidyl)dodecane dihydroiodide → 1,12-Bis(2-amino-3,4,5,6-tetrahydropyrimidyl)dodecane diacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,12-Bis(2-amino-3,4,5,6-tetrahydropyrimidyl)dodecane dihydroiodide | HCID 19088834 | — |
| Reactant | Methanol--water (1/1) | HCID 22242641 | — |
| Product | 1,12-Bis(2-amino-3,4,5,6-tetrahydropyrimidyl)dodecane diacetate | HCID 67867054 | — |
Reaction Steps
30.0 g (0.048 mol) of 1,12-bis(2-amino-3,4,5,6-tetrahydropyrimidyl)dodecane dihydroiodide in 300 ml of methanol/water (1:1) were filtered through a column containing 250 g of ion exchanger (OH- form). The free guanidine base obtained after working up was dissolved in methanol and converted into the diacetate with excess glacial acetic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05242948 |
| Source dataset | uspto-grants-1993_09 |
| ORD ID | ord-62caf7e77d574b0eacf847ea9cbf3833 |
| Source note | uspto-grants-1993_09 |